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Meanwhile, altered regions in the LGG patients was obtained and various nodal parameters were further calculated in each region. Results: From the graph-based topological metrics of the constructed network, various global parameters changed significantly in LGG patients. The two-factor variance analysis was used to investigate the influence of operation and lesion location on whole-brain and hemisphere networks. Statistical analyses were performed to reveal the significant differences of various network characteristics between LGG patients and NC as well as between LGG patients before and after operation. Brain hub nodes and random nodes between LGG and NC were compared. The structural connections were established by selecting an appropriate connectivity threshold.
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Method : We constructed whole-brain and hemisphere anatomical networks for 20 LGG patients and 20 normal controls (NC). On this basis, the structural plasticity and function compensatory mechanism of LGG patient were discussed. This study aimed to analyze the topological properties of brain structural networks in LGG patients and investigate the influence of operation and lesion location on whole-brain and hemisphere networks. Purpose: At present, few studies have investigated the functional performance in patients with low grade glioma (LGG) from the perspective of brain structural characteristics.